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The Cancer Letter Inc.
PO Box 9905
DC 20016
Tel: 202-362-1809
Fax: 202-379-1787
publication date: Jun 2, 2016
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NCI CTEP-Approved Trials for the Month of May


The National Cancer Institute Cancer Therapy Evaluation Program approved the following clinical research studies last month. For further information, contact the principal investigator listed.


Phase I

9899: A Phase 1 Trial of the Combination of the Heat Shock Protein-90 (HSP90) Inhibitor Onalespib (AT13387) and the Cyclin-Dependent Kinase (CDK) Inhibitor AT7519M in Patients with Advanced Solid Tumors. Dana-Farber - Harvard Cancer Center LAO; Do, Khanh Tu. (617) 632-6992


9930: A Phase I Trial of MEDI-570 in Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma (PTCL) Follicular Variant and Angioimmunoblastic T-Cell Lymphoma (AITL). University Health Network Princess Margaret Cancer Center LAO; Chavez, Julio C. (813) 745-1867


Phase II

9875: Phase 2 Study of AT13387 (onalespib) in ALK+ ALCL, MCL, and BCL-6+ DLBCL. Dana-Farber - Harvard Cancer Center LAO; Jacobson, Caron Alyce. (617) 582-7591


9881: A Phase 2 Study of Cediranib in Combination with Olaparib in Advanced Solid Tumors. Yale University Cancer Center LAO; Kim, Joseph Woong. (203) 737-1600


Phase III

EA5142: Adjuvant Nivolumab in Resected Lung Cancers (ANVIL)-A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers. ECOG-ACRIN Cancer Research Group; Chaft, Jamie Erin. (646) 888-4543


Other Phases

10018: Randomized Trial of Financial Incentives for Research Participation. University of Pennsylvania/Abramson Cancer Center; Halpern, Scott David. (215) 898-1462


ACNS14B2-Q: Examination of Molecular Alterations of Potential Diagnostic, Prognostic and Therapeutic Utility Among Pediatric Low-Grade Gliomas (PLGGs) Treated on the Children’s Oncology Group Clinical Trial, A9952. Children’s Oncology Group; Eberhart, Charles G. (410) 502-5185


AOST15B2-Q: Validation of a Plasma MicroRNA Panel as a Biomarker for Osteosarcoma. Children’s Oncology Group; Allen-Rhoades, Wendy (832) 824-4207


ARST16B1-Q: Utilizing the Collaborative PedsTCC Infrastructure Towards Molecular Discovery of Novel Translocations and the Exomic Mutational Landscape in Embryonal Sarcoma. Children’s Oncology Group; Setty, Bhuvana Anantha. (614) 722-3550


ARST16B2-Q: Investigating the Role of the Transcriptional Co-Activator TAZ (Transcriptional Co-Activator with PDZ-Binding Motif) in Alveolar Rhabdomyosarcoma. Children’s Oncology Group; Linardic, Corinne Mary. (919) 684-3401


EAQ152: COMET - Communication and Education in Tumor Profiling: A Randomized Study of Pre-Disclosure Genetic Education v. Usual Care in Tumor Profiling for Advanced Cancer and a Pilot Study of Remote Genetic Counseling for Participants with Potential Germline Mutations Identified on Tumor Profiling. ECOG-ACRIN Cancer Research Group; Bradbury, Angela R. (215) 615-3341

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