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The Cancer Letter Inc.
PO Box 9905
DC 20016
Tel: 202-362-1809
Fax: 202-379-1787
publication date: Mar 31, 2016
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Ovarian Cancer

Study: Reolysin-Paclitaxel Combination Demonstrates Higher Response than Paclitaxel Therapy Alone


Updated results from a phase II trial of Reolysin and paclitaxel in ovarian cancer patients showed that an intent-to-treat analysis of tumor response, as assessed by CA-125 antigen levels, demonstrated statistically significantly higher full response rates and stable disease or better rates in the test arm compared to paclitaxel alone.

The rate of full responses in the combination arm was 9.26 percent, compared to 1.85 percent in the control arm (p = 0.0196). The rate of stable disease or better in the test arm was 44.44 percent, compared with 24.08 percent in the control arm (p = 0.0096).

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