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The Cancer Letter Inc.
PO Box 9905
DC 20016
Tel: 202-362-1809
Fax: 202-379-1787
publication date: Nov 3, 2015
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Study: Lenvatinib-Everolimus Combination Can Improve PFS in Renal Cell Carcinoma


Lenvatinib, used in combination with everolimus, demonstrated significantly improved progression-free survival compared everolimus alone in people with metastatic renal cell carcinoma following prior VEGF-targeted therapy in a phase II trial.

PFS was 14.6 months when treated with the lenvatinib-everolimus combination, compared to 5.5 months in the control arm (HR=0.40; 95% CI: 0.24-0.68; p<0.001).

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