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The Cancer Letter Inc.
PO Box 9905
DC 20016
Tel: 202-362-1809
Fax: 202-379-1787
publication date: Nov 3, 2015
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WT1 Vaccine Doubles PFS in MPM Patients in Phase II Trial


A phase II clinical study of the WT1 cancer vaccine, developed by SELLAS Life Sciences Group, showed increased median overall survival in patients with malignant pleural mesothelioma.

Patients that received WT1 demonstrated an OS of 39 months compared to 18 months in the control arm. In addition, WT1 treatment resulted in a median progression-free survival of 11.5 months, more than double that of the control arm’s 5.5 months.

The double-blinded, randomized study compared WT1 analog peptides vaccine in combination with Montanide-adjuvant plus granulocyte-macrophage colony-stimulating factor, versus Montanide-adjuvant plus GM-CSF in patients with MPM who had previously completed combined modality therapy.

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