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The Cancer Letter Inc.
PO Box 9905
Washington
DC 20016
Tel: 202-362-1809
Fax: 202-379-1787
publication date: Nov 3, 2015
October 2015 PDF



 

Drugs and Targets

FDA Approves Imlygic as First Oncolytic Viral Therapy in the U.S., for Melanoma

FDA approved Imlygic (talimogene laherparepvec) as the first oncolytic viral therapy in the U.S.

Imlygic, developed by Amgen, is indicated for the local treatment of unresectable cutaneous, subcutaneous and nodal lesions in patients with melanoma recurrent after initial surgery. Imlygic has not been shown to improve overall survival or have an effect on visceral metastases.

Imlygic is a genetically modified herpes simplex virus type 1 designed to replicate within tumors and produce granulocyte-macrophage colony-stimulating factor, an immunostimulatory protein. Imlygic causes cell lysis rupturing tumors and releasing tumor-derived antigens, which along with GM-CSF, may promote an anti-tumor immune response. However, the exact mechanism of action is unknown, according to Amgen.

Also:

 

Breast Cancer

Phase III Trial Finds Equivalent OS Rates Between APBI Brachytherapy and Whole Breast Irradiation Therapy

A prospective, randomized, multicenter phase III study comparing accelerated partial breast irradiation with interstitial multicatheter brachytherapy to whole breast irradiation showed that APBI brachytherapy lead to equivalent overall survival and local and regional cancer control rates, as compared to WBI after breast conserving surgery for selected patients with early stage breast cancers.

The primary objective of the trial was to assess the role of APBI brachytherapy alone compared to whole breast irradiation with boost in a defined group of patients with invasive (stage I-IIA) breast cancer or ductal carcinoma in situ (stage 0) who underwent breast-conserving surgery.

     

    Non-Small Cell Lung Cancer

    Patients Receiving IMRT Had Less Toxicity Compared to 3D CRT, Study Finds

    Patients with locally advanced non-small cell lung cancer that received intensity modulated radiation therapy had less severe lung toxicity and were able to better tolerate their chemotherapy compared to patients who received 3D conformal radiation therapy, according to a secondary analysis of a large phase III trial.

    The study, NRG/RTOG 0617, originally enrolled patients from 2007 to 2011, and compared a high dose of 74 Gy to the standard dose of 60 Gy. All underwent concurrent chemotherapy (carboplatin/paclitaxel, with or without cetuximab) and either 3D CRT or IMRT. In the study, 482 patients were treated with radiation—53 percent with IMRT and 47 percent with 3-D CRT.

       

      Prostate Cancer

      Phase III Trial Demonstrates Shorter, Hypofractionated RT Can Deliver Similar Results Compared to Conventional RT

       

      Mesothelioma

      WT1 Vaccine Doubles PFS In MPM Patients in Phase II Trial

       

      Renal Cell Carcinoma

      Study: Lenvatinib-Everolimus Combination Can Improve PFS

       

      Carcinoid Syndrome

      Telotristat Etiprate Demonstrates Clinical Benefit in Phase III Study

       

      Cervical Cancer

      Outreach Program Boosts HPV Vaccine Three-Dose Series Completion

       

      NCI CTEP-Approved Trials For the Month of October


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